Tante Girang P45.dependen

Tante Girang P45.dependen cytochrome oxidase enzyme, which plays a role in biotransformation and detoxification reaction intermediate compounds and metabolites xenobiotik, will also generate peroxide compounds or reactive oxygen compounds

In normal conditions, the formation of hydrogen peroxide is not so dangerous. However, the presence of transition metals such as Cu and Fe will form a very dangerous hydroxyl radical, via the Haber-Weiss reaction and Fenton. For example the enzyme monoamine oxidase, the presence of isoenzymes of different shapes to form hydrogen peroxide in peripheral tissues. Fe or Cu metal will react with hydroxyl radicals, and then will destroy the cell structure. Macrophage and neutrophil activation is a form of the body's defense mechanism against infectious microorganisms. In this case the oxidase and oxygenase enzymes to form various compounds free radicals and reactive oxygen compounds, including hipoklorid acid (HOO), which will attack and destroy viruses and bacteria. But on the other hand, the formation of radical compounds are also potentially very dangerous because it attacks the body's cells. Fe or Cu metal will react with hydroxyl radicals, and then will destroy the cell structure. Macrophage and neutrophil activation is a form of the body's defense mechanism against infectious microorganisms. In this case the oxidase and oxygenase enzymes to form various compounds free radicals and reactive oxygen compounds, including hipoklorid acid (HOO), which will attack and destroy viruses and bacteria. But on the other hand, the formation of radical compounds are also potentially very dangerous because it attacks the body's cells. If this is not controlled properly by the body's defense system, will trigger the emergence of various chronic diseases, particularly rheumatoid symptomatic, which is ldinis known as autoimmune disease. For example, the occurrence of cardiac miopatia poliartritis don an adult, Streptococcus and Staphylococcus infections, glomerulo nephritis, and others.