Tante Girang Analgesics Perifer Classification Chemically, peripheral analgesics can be divided into several groups, namely:a. paracetamol. b. salicylate: asetosal, salisilamida and benorilat c. prostaglandin inhibitors (NSAIDs): ibuprofen, etc. d. derivatives-antranilat: mefenaminat, glafenin. e. derivatives-pirazolinon: propifenazon, isopropilaminofenazon and metamizol f. Other: benzidamin (Tantum)
Co-analgesic efficacy is a drug and its main indication is not banish pain, eg. antidepresiva trisiklis (amitriptyline) and antiepileptika (carbamazepine, pregabalin, fenytoin, valproic). These drugs are used alone or combined with other analgesics in certain circumstances, such as neuropathic pain.
Use
These medications can relieve or eliminate pain without affecting the CNS or lose consciousness, also does not cause addiction. Most of these substances are also helpless antipiretis and / or anti-inflammatory. It is therefore not only used as a drug antinyeri, but also at a fever (a viral infection / germs, colds, runny nose) and inflammation such as rheumatism and gout. These drugs are often given for mild to moderate pain, which causes diverse, such as headache, teeth, muscles or joints (Rema, gout), stomach, menstrual pain (dystnenorroe), pain due to collision or accident (trauma). For the second last pain, NSAIDs are more feasible. In more severe pain eg. after surgery or fracture (broken bone), it works less potent.
* Power antipiretisnya herdasarkan heat stimulation of the central regulator in the hypothalamus, which causes peripheral vasodilatation (the skin) with the increase in spending a lot of heat that accompanied the release of sweat.
* Power-inflammatory (antiflogistis). Most anti-inflammatory analgesics have dava, especially a large group of substances prostaglandin inhibitors (NSAIDs, including asetosal), as well as benzidamin. Zatzat are widely used for pain accompanied by inflammation, Rheumatic Drugs.
* The combination of two or more analgesic often used, because there potentiation effect. Besides side effects, each of which is located in a different field, can be reduced, because the dose of each component can be derived. Combination analgesics with kofein and codeine are frequently used, especially in preparations with paracetamol and asetosal.
Side effects
The most common are gastrointestinal disorders, damage to blood, liver and kidney damage and allergic skin reactions. These side effects occur mainly on the use of old or in high doses. Therefore the use of anal-getika continuously is not recommended.
Interaction
Most analgesics strengthen antikoagulansia effect, except for paracetamol and glafenin. Both of these drugs in normal doses can be combined safely for a maximum period of two weeks.
Pregnancy and Lactation
Only paracetamol is considered safe for pregnant and lactating women, although it can reach the milk. Asetosal and salicylates, NSAIDs and metamizol can interfere with fetal development, so that should be avoided. From propifenazon aminofenazon and there has not been enough data.
